Tag: Biology

  • [Solved] expressing

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    Being able to tell a good story, involves details and descriptions. Why is telling an accurate story, with vivid descriptions sometimes difficult for novice writers? How was your experience learning about narrative writing, – 2 years ago

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    Being able to tell a good story, involves details and descriptions. Why is telling an accurate story, with vivid descriptions sometimes difficult for novice writers? How was your experience learning about narrative writing,

    – 2 years ago

  • [Solved] No ai or plagiarism (6hrs)

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    "Consider that the net wealth of a typical Black family in America is around one-tenth that of a white family. A 2018 analysis of U.S. incomes and wealth written by economists Moritz Kuhn, Moritz Schularick, and Ulrike I. Steins and published by the [Federal Reserve Bank of Minneapolis](https://www….

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    "Consider that the net wealth of a typical Black family in America is around one-tenth that of a white family. A 2018 analysis of U.S. incomes and wealth written by economists Moritz Kuhn, Moritz Schularick, and Ulrike I. Steins and published by the [Federal Reserve Bank of Minneapolis](https://www.minneapolisfed.org/research/institute-working-papers/income-and-wealth-inequality-in-america-1949-2016) concluded, "The historical data also reveal that no progress has been made in reducing income and wealth inequalities between black and white households over the past 70 years." (See [https://news.harvard.edu/gazette/story/2021/06/racial-wealth-gap-may-be-a-key-to-other-inequities/](https://news.harvard.edu/gazette/story/2021/06/racial-wealth-gap-may-be-a-key-to-other-inequities/))

    ##### **Instructions**

    Using U.S. family incomes, construct a slide presentation that differentiates between equality, equity, and justice. Be sure to address the following:

    1. Define equality, equity, and justice (cite 1 scholarly source).
    2. List 2 background needs that U.S. Lawmakers should consider if Black and White American families are to achieve not only income equality but income equity and income justice.
    3. What are some types of income experiences that contribute to income equality, equity, and justice for Black and White families? Use U.S. family incomes/quantitative data and qualitative excerpts (people's stories) to illustrate differences between equality, equity, and justice and show income shifts experienced by Black and White American families.

    **Slide Breakdown:**

    – The first slide should be a cover page, and the final slide should be a reference page.
    – The second slide should present your thesis statement: "This report will …"
    – The remaining slides should contain infographics, content addressing the topics and questions, and correctly cited supportive scholarly sources.

    – 2 years ago

  • [Solved] Biology homework

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    **Create** a 3- to 4-page (excluding visual elements) Medication Study Guide for your assigned psychotropic medication agents that may be utilized by you and colleagues for study. Your medication guide should be in the form of an outline and should include a title page, citations, and references. Yo…

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    **Create** a 3- to 4-page (excluding visual elements) Medication Study Guide for your assigned psychotropic medication agents that may be utilized by you and colleagues for study. Your medication guide should be in the form of an outline and should include a title page, citations, and references. You should incorporate visual elements, such as concept maps, charts, diagrams, images, color coding, mnemonics, and/or flashcards. Be creative!

    – 2 years ago

  • [Solved] lead

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  • [Solved] a5

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  • [Solved] a5

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  • [Solved] a5

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  • [Solved] a5

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  • [Solved] S44

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    – 2 years ago **files (1)** – ## S44.docx **## S44.docx** In this lab project, you will work with the En-ROADS simulation model developed by Climate Interactive and MIT Sloan Sustainability Initiative to create a scenario that can mitigate [global warmingLinks to an external site.](https://education…

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    – 2 years ago

    **files (1)**

    – ## S44.docx

    **## S44.docx**

    In this lab project, you will work with the
    En-ROADS simulation model developed by Climate Interactive and MIT Sloan Sustainability Initiative to create a scenario that can mitigate
    [global warmingLinks to an external site.](https://education.nationalgeographic.org/resource/global-warming/) to the internationally agreed target of less than 2 °C, and ideally 1.5 °C. En-ROADS is an interactive tool for simulating the long-term impacts of policy actions on global warming. This includes policies affecting energy supply, energy efficiency, carbon emissions prices, land use, and other factors that can reduce greenhouse gas emissions. Since En-ROADS is a global model, the policy levers simulate if the action were applied to the entire world. En-ROADS does not attempt to address the complex nuances of how different countries and political groups might respond to each policy.

    En-ROADS is grounded in the best-available science about climate impacts; solutions; and the complex interactions of the climate, energy, land, population, and economic systems. As you are completing the En-ROADS simulation model, and work toward your mission of recommending global policies and investments, keep the following goals in mind:

    ·
    **Limit global warming.** Global warming above 2 °C will cause dangerous and irreversible impacts that will harm our prosperity, security, health, and lives. Limiting warming to less than 2 °C is not without challenges either (we are already seeing impacts today); however, it is a benchmark by which scientists and world leaders believe we can lower the risks to a more manageable level.

    ·
    **Preserve and create a healthy economy.** Your policies should strive to lead a global energy transition that would preserve and create a healthy global economy. You must decide how to balance the short-term costs of climate actions with the long-term costs of damages from climate inaction. Note that financial costs are not explicitly predicted in the model as they are uncertain and controversial. You may offer your own hypotheses on the financial impacts of different decisions.

    · While assessing the economics, also consider the potential to offset short-term costs with additional cobenefits, for example, benefits to the economy, public health, national security, and other areas which could augment the direct benefits of mitigating global warming.

    ·
    **Promote equity and a just transition.** Consider the impacts of your policies for both developed and developing countries, and between the rich and poor people within such nations. Consider whether your policies will disproportionately harm certain groups and how to mitigate such harms (e.g., If you favor policies that would reduce or shut down fossil fuel use, how will your policies address the resulting unemployment of people employed by the fossil fuel industry?). Also consider how opportunities for the new green economy can be shared more equitably and not leave marginalized groups behind.

    ·
    **Protect the environment.** Many environmental challenges besides climate change threaten human welfare—for example, water shortage, air and water pollution (smogLinks to an external site., particulatesLinks to an external site.), soil loss, plastic pollution,
    [anoxic zones (dead zones)Links to an external site.](https://oceanservice.noaa.gov/facts/deadzone.html) in rivers and oceans, extinction of species, and so on. Your proposals should minimize these other harmful effects on the environment.

    ·
    **Be realistic but not cynical.** Imagine a scenario of what could be possible if human civilization operates at its best.

    ·
    **Submit a write-up expressing your vision.** After developing your preferred scenario, write a thoughtful and concise response to the questions that follow in this prompt. Develop your vision and approach on the issues. Instructions on how to format your write-up are at the end of this activity prompt.

    Your En-ROADS lab assignment will be a 3- to 5-page memo describing your proposal.

    Provide a short, memorable name for your plan
    2. Paste a screenshot of the main En-ROADS interface showing your results
    3. Present bullet points summarizing your most important policies and outcomes
    4. Paste the text from Actions & Outcomes to document all the assumptions and policy
    settings you choose in your scenario, formatting the content so it looks more like the
    sample in the template (font size 11, no bold text).Access the “Actions & Outcomes”
    feature from the “View” menu.
    Figure 1: Actions & Outcomes
    Paste your URL from the “Copy scenario link” option in the Share Your
    Scenario feature on the top tool bar
    Figure 2: Copy scenario link
    Illustrative Example
    The example on the following pages is illustrative only. Note that the policies shown in
    the example do not reduce expected global warming to below 2 degrees C. Your
    preferred strategy should attempt to do so. Please note that due to updates to the EN-
    ROADS activity website, some of the visual representation may look a little different.

    Summary:
    My proposals favor technological innovation over regulation and taxes by providing:
    • Large subsidies for nuclear energy
    • Heavy investment in R&D to yield cheap fusion power (New Tech)
    • Large subsidies and investment to develop technologies to remove carbon from
    the atmosphere
    • Reduce emissions of non-CO2 greenhouse gases through innovation
    • Yields expected warming of 3.0C (5.4F) by 2100.
    • I believe aggressive tax and/or regulatory policies to mitigate emissions are
    politically difficult. Our proposal therefore stresses policies to stimulate R&D
    aimed at bringing nuclear back and, eventually, introducing new technologies
    that, while not feasible or cost-effective today, promise carbon- free electricity
    cheaper than coal, along with technologies like DAC (direct air capture of CO2),
    BECCS (bioenergy with carbon capture and sequestration), and others that can
    remove CO2 from the atmosphere. These policies do not meet the 2°C goal, but
    we believe that additional technological innovation, as yet unknown, will enable
    society to adapt to a world with 3°C of warming by 2100.
    PAGE 1

    · Tech Breakthroughs: Nuclear, Fusion, Carbon Removal
    Scenario Policies:
    Nuclear
    Nuclear (tax/subsidy) = -0.03 $/kWh
    New Zero-Carbon
    New Zero-Carbon breakthrough = 1
    Methane & Other Gases
    Methane and other gases (reduce/increase) = -12 %
    Technological Carbon Removal
    Technological carbon removal (% of max potential) = 56 %
    Temperature Increase in 2100
    3.0 ºC / 5.4 ºF
    CO2 Concentration in 2100
    572 ppm
    Sea Level Rise in 2100
    0.6 m / 2.2 ft
    Cumulative Avoided CO2 by 2100
    647 gigatons CO2
    Discounted Cumulative Damage through 2100
    5,772 trillion $
    SCENARIO LINK:
    https://en-roads.climateinteractive.org/scenario.html?v=23.12.0&p30=-
    0.03&p35=1&p59=-12&p67=56&g0=2&g1=62

    **Climate:** How well do you think your proposal does in meeting the Paris climate goals? If it does not meet the goal, why is this acceptable to you?

    ·
    **Economy:** If the world followed your recommendations, how would the economy be different at various points in the future, for example, 2030, 2050, and 2100, and so on? In what ways would it be better? In what ways would it be worse?

    ·
    **Equity:** How can your proposal strive to increase equity across different nations and different peoples?

    ·
    **Environment:** To what extent might your proposal mitigate other environmental challenges (e.g., biodiversity, pollution, water, and air quality)? To what extent might your proposal cause or worsen other environmental problems?

    ·
    **Realism without cynicism:** What would it take for your proposal to be realized? What barriers might arise in the implementation of your proposals, and how might they be addressed? To get started, what actions and priorities are needed as soon as possible from businesses, civil society, governments, or the public?

    ·
    **Winners/Losers:** Who would be the biggest winners and losers globally in your proposed future? Create a table with two columns for winners and losers.

    ·
    **Surprises from En-ROADS:** What surprised you about the behavior of the energy and climate system as captured in the simulation? For example, what actions had a bigger or smaller effect than you thought? Did you discover why?

    ·
    **Feelings:** How did your insights from the model and this assignment make you feel? (feelings as in emotions, not thoughts)

    ·
    **Hope and personal action:** Do any trends in the world give you hope that your proposals are possible? What can you personally do to help create the necessary changes?

    The Simulating Climate Futures in En-ROADS Laboratory memo write-up,

    · must be 3 to 5 double-spaced pages in length (not including title and references pages)

    **## S44.docx**

    In this lab project, you will work with the
    En-ROADS simulation model developed by Climate Interactive and MIT Sloan Sustainability Initiative to create a scenario that can mitigate
    [global warmingLinks to an external site.](https://education.nationalgeographic.org/resource/global-warming/) to the internationally agreed target of less than 2 °C, and ideally 1.5 °C. En-ROADS is an interactive tool for simulating the long-term impacts of policy actions on global warming. This includes policies affecting energy supply, energy efficiency, carbon emissions prices, land use, and other factors that can reduce greenhouse gas emissions. Since En-ROADS is a global model, the policy levers simulate if the action were applied to the entire world. En-ROADS does not attempt to address the complex nuances of how different countries and political groups might respond to each policy.

    En-ROADS is grounded in the best-available science about climate impacts; solutions; and the complex interactions of the climate, energy, land, population, and economic systems. As you are completing the En-ROADS simulation model, and work toward your mission of recommending global policies and investments, keep the following goals in mind:

    ·
    **Limit global warming.** Global warming above 2 °C will cause dangerous and irreversible impacts that will harm our prosperity, security, health, and lives. Limiting warming to less than 2 °C is not without challenges either (we are already seeing impacts today); however, it is a benchmark by which scientists and world leaders believe we can lower the risks to a more manageable level.

    ·
    **Preserve and create a healthy economy.** Your policies should strive to lead a global energy transition that would preserve and create a healthy global economy. You must decide how to balance the short-term costs of climate actions with the long-term costs of damages from climate inaction. Note that financial costs are not explicitly predicted in the model as they are uncertain and controversial. You may offer your own hypotheses on the financial impacts of different decisions.

    · While assessing the economics, also consider the potential to offset short-term costs with additional cobenefits, for example, benefits to the economy, public health, national security, and other areas which could augment the direct benefits of mitigating global warming.

    ·
    **Promote equity and a just transition.** Consider the impacts of your policies for both developed and developing countries, and between the rich and poor people within such nations. Consider whether your policies will disproportionately harm certain groups and how to mitigate such harms (e.g., If you favor policies that would reduce or shut down fossil fuel use, how will your policies address the resulting unemployment of people employed by the fossil fuel industry?). Also consider how opportunities for the new green economy can be shared more equitably and not leave marginalized groups behind.

    ·
    **Protect the environment.** Many environmental challenges besides climate change threaten human welfare—for example, water shortage, air and water pollution (smogLinks to an external site., particulatesLinks to an external site.), soil loss, plastic pollution,
    [anoxic zones (dead zones)Links to an external site.](https://oceanservice.noaa.gov/facts/deadzone.html) in rivers and oceans, extinction of species, and so on. Your proposals should minimize these other harmful effects on the environment.

    ·
    **Be realistic but not cynical.** Imagine a scenario of what could be possible if human civilization operates at its best.

    ·
    **Submit a write-up expressing your vision.** After developing your preferred scenario, write a thoughtful and concise response to the questions that follow in this prompt. Develop your vision and approach on the issues. Instructions on how to format your write-up are at the end of this activity prompt.

    Your En-ROADS lab assignment will be a 3- to 5-page memo describing your proposal.

    Provide a short, memorable name for your plan
    2. Paste a screenshot of the main En-ROADS interface showing your results
    3. Present bullet points summarizing your most important policies and outcomes
    4. Paste the text from Actions & Outcomes to document all the assumptions and policy
    settings you choose in your scenario, formatting the content so it looks more like the
    sample in the template (font size 11, no bold text).Access the “Actions & Outcomes”
    feature from the “View” menu.
    Figure 1: Actions & Outcomes
    Paste your URL from the “Copy scenario link” option in the Share Your
    Scenario feature on the top tool bar
    Figure 2: Copy scenario link
    Illustrative Example
    The example on the following pages is illustrative only. Note that the policies shown in
    the example do not reduce expected global warming to below 2 degrees C. Your
    preferred strategy should attempt to do so. Please note that due to updates to the EN-
    ROADS activity website, some of the visual representation may look a little different.

    Summary:
    My proposals favor technological innovation over regulation and taxes by providing:
    • Large subsidies for nuclear energy
    • Heavy investment in R&D to yield cheap fusion power (New Tech)
    • Large subsidies and investment to develop technologies to remove carbon from
    the atmosphere
    • Reduce emissions of non-CO2 greenhouse gases through innovation
    • Yields expected warming of 3.0C (5.4F) by 2100.
    • I believe aggressive tax and/or regulatory policies to mitigate emissions are
    politically difficult. Our proposal therefore stresses policies to stimulate R&D
    aimed at bringing nuclear back and, eventually, introducing new technologies
    that, while not feasible or cost-effective today, promise carbon- free electricity
    cheaper than coal, along with technologies like DAC (direct air capture of CO2),
    BECCS (bioenergy with carbon capture and sequestration), and others that can
    remove CO2 from the atmosphere. These policies do not meet the 2°C goal, but
    we believe that additional technological innovation, as yet unknown, will enable
    society to adapt to a world with 3°C of warming by 2100.
    PAGE 1

    · Tech Breakthroughs: Nuclear, Fusion, Carbon Removal
    Scenario Policies:
    Nuclear
    Nuclear (tax/subsidy) = -0.03 $/kWh
    New Zero-Carbon
    New Zero-Carbon breakthrough = 1
    Methane & Other Gases
    Methane and other gases (reduce/increase) = -12 %
    Technological Carbon Removal
    Technological carbon removal (% of max potential) = 56 %
    Temperature Increase in 2100
    3.0 ºC / 5.4 ºF
    CO2 Concentration in 2100
    572 ppm
    Sea Level Rise in 2100
    0.6 m / 2.2 ft
    Cumulative Avoided CO2 by 2100
    647 gigatons CO2
    Discounted Cumulative Damage through 2100
    5,772 trillion $
    SCENARIO LINK:
    https://en-roads.climateinteractive.org/scenario.html?v=23.12.0&p30=-
    0.03&p35=1&p59=-12&p67=56&g0=2&g1=62

    **Climate:** How well do you think your proposal does in meeting the Paris climate goals? If it does not meet the goal, why is this acceptable to you?

    ·
    **Economy:** If the world followed your recommendations, how would the economy be different at various points in the future, for example, 2030, 2050, and 2100, and so on? In what ways would it be better? In what ways would it be worse?

    ·
    **Equity:** How can your proposal strive to increase equity across different nations and different peoples?

    ·
    **Environment:** To what extent might your proposal mitigate other environmental challenges (e.g., biodiversity, pollution, water, and air quality)? To what extent might your proposal cause or worsen other environmental problems?

    ·
    **Realism without cynicism:** What would it take for your proposal to be realized? What barriers might arise in the implementation of your proposals, and how might they be addressed? To get started, what actions and priorities are needed as soon as possible from businesses, civil society, governments, or the public?

    ·
    **Winners/Losers:** Who would be the biggest winners and losers globally in your proposed future? Create a table with two columns for winners and losers.

    ·
    **Surprises from En-ROADS:** What surprised you about the behavior of the energy and climate system as captured in the simulation? For example, what actions had a bigger or smaller effect than you thought? Did you discover why?

    ·
    **Feelings:** How did your insights from the model and this assignment make you feel? (feelings as in emotions, not thoughts)

    ·
    **Hope and personal action:** Do any trends in the world give you hope that your proposals are possible? What can you personally do to help create the necessary changes?

    The Simulating Climate Futures in En-ROADS Laboratory memo write-up,

    · must be 3 to 5 double-spaced pages in length (not including title and references pages)

  • [Solved] 1800 words CASE STUDY ON DRUG TARGET VALIDATION

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    **Order Information:** Drug Target Validation Case Study. In this component, writer present the evidence for the proof of concept and validation of a drug target for a biologic. In this case this will be infliximab, the pathfinding biologic that has revolutionised the treatment of rheumatoid arthrit…

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    **Order Information:** Drug Target Validation Case Study.  In this component, writer present the evidence for the proof of concept and validation of a drug target for a biologic. In this case this will be infliximab, the pathfinding biologic that has revolutionised the treatment of rheumatoid arthritis. This is based on a lecture and problem based learning session that has discussed the process toward the discovery of TNF as a molecule of major importance, and proof that its inhibition may be of benefit to rheumatoid arthritis patients, to the first clinical trial, and then the phase-II trial that finally proved the clinical efficacy. The writer should structure this according to the priorities they feel are important to the progress and success of the biologic, with headings. The study should be well presented, fit for showing to a future employer. The Study should: • Relate the progress of ideas as they occurred. • Present evidence from original and contemporaneous scientific papers with only essential reference to reviews and no reference to textbooks. • Use the Cite it Right referencing format. Using Endnote would be recommended. • Cover the discovery of TNF as a target relating to the classical stages of preclinical validation of a drug target, namely: o Is the target up-regulated in the appropriate disease state? o Is spatial and temporal expression consistent with the proposed role in the disease pathology? o Does removal or inhibition of the target ameliorate signs for which it is thought to be responsible? o Does increasing the activity of the target exacerbate signs for which it is thought responsible? o The report should not use these as titles or headings. Sections should be created according to the message the writer wishes to convey. • Evaluate the contribution animal models made to the discovery • Describe the design of the biological therapeutics cA2 and infliximab • Relate these to the proof of concept clinical trial for cA2, and the ATTRACT infliximab trial. Important objective for the writer- 1.identify the inflammatory disease in this case (arthritis) and the cytokinesis involved. 2.Role of the cytokinesis involved and the mode of action. e.g.cytokines-TNF alpha,IL-1 as a target 3.Can the target be identified and does it have a role in the disease. 4.Can the drug target be modified,optimising it . 5.Is the drug design development 6.Pre clinical and clinical developments (Phase I,PhaseII,PhaseIII) The citation style has to be in harvard references . We were instructed to prepare the case study as a scientist and the audience for this case study are scientist as well. It is very important to present graphs,tables and figures to support the evidence in each headingsThese graphs,tables and figures are from the published articles and not from the reviews.The maximum words should be 1000-1300 not more than that ,and these words are excluding the references ,graphs tables and figures.

    – 2 years ago

    **1800 words CASE STUDY ON DRUG TARGET VALIDATION**

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